Caption |
Lung: a pulmonary metastasis of a mammary adenocarcinoma is composed of large lobules separated by a scant amount of fibrovascular stroma. Neoplastic lobules are solid and neoplastic cells form secondary lumens (arrowheads). Numerous large areas of liquefactive necrosis are present at the center of neoplastic lobules. There is prominent nuclear palissading at the periphery of neoplastic lobules. Neoplastic cells are polygonal to columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm that often contains a few small optically empty vacuoles (lipids?). The nucleus is central, oriented in the long axis of neoplastic cells, oval, medium-size and hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous. |
