Pathology Image Detail

Caption

Mammary gland: the neoplasm is locally invasive. It is composed of glands and 3-6 cells-thick trabeculae supported by a moderate amount of fibrovascular stroma with a mild lymphocytic and plasmacytic inflammation. Neoplastic cells are polygonal to low columnar, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, oval, medium-sized, hypochromatic and with 1-3 medium-size to large amphophilic nucleoli. Anisocytosis and anisokaryosis are mild to moderate. Mitoses are numerous. Numerous neoplastic cells undergo apoptosis.

Description

Adenocarcinoma, glandular and trabecular, mammary gland

Age at Necropsy

240 days

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29281
Tumor Name
Mammary gland • adenocarcinoma - trabecular
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular and trabecular, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
240 days