Pathology Image Detail

Caption	Glandular mammary adenocarcinoma: the neoplasm is composed of closely-packed papillae and glands supported by a scant amount of fibrovascular stroma. There are large coalescing areas of coagulation necrosis at the center of the neoplasm. Neoplastic cells form glands lined by a one cell-thick low columnar to cuboidal epithelium supported by a scant amount of fibrovascular stroma. Many neoplastic glands are dilated by desquamated and degenerated neoplastic cells. Neoplastic often pile-up disorderly up to 5 cells-thick. Neoplastic cells are cuboidal to columnar with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm. The nucleus is central, oval, and slightly hyperchromatic.
Description	Adenocarcinoma, glandular and papillary, with prominent coagulation necrosis, mammary gland
Age at Necropsy	unknown
Contributor	Ward JM (J:107304)
Pathologist	Mikaelian I (J:94320)
Method	H&E

Tumor Synonyms: Adenocarcinoma, glandular and papillary, with prominent coagulation necrosis, mammary gland

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.