Pathology Image Detail

Caption

Mammary gland: the neoplasm is composed of coalescing lobules separated by thick fibrovascular septae. The center of the lobules is generally cystic and occasionally contains tissues that have undergone coagulation necrosis and hemorrhage (*). Neoplastic lobules are composed of closely-packed glands generally lined by a one cell-thick cuboidal epithelium. Neoplastic cell occasionally pile-up disorderly (up to 4-5 cells-thick) but retain the ability to form secondary lumens.

Description

Adenocarcinoma, glandular, acinar, cystic, solid with secondary lumens, mammary gland

Age at Necropsy

unknown

Notes

This tumor forms fronds that are reminiscent of fronds observed in type P tumors. However, this neoplasm differs from type P tumors in that the mitotic activity is not most important at the tip of the fronds and ductal differentiation with squamous metaplasia are absent.

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29296
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, acinar, cystic, solid with secondary lumens, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
STOCK Tg(MMTV-S100a4)507Oku
Strain Types
transgenic
General Note
This STOCK genetic background was a mixture of C57BL/6, GRS/A, and CBA.
Strain Synonyms
GRS/A-Tg(MMTVS100a4)xElu
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown