Pathology Image Detail

Caption

Mammary gland: at its' periphery, the neoplasm formed hollow frond-like structures that contained a proteinaceous fluid with a few degenerated neoplastic cells. In these areas, the basal layers of the neoplastic epithelium clearly showed nuclear palissading. This type of nuclear palissading is reminiscent of myoepithelial differentiation that is observed in type P tumors. However, unlike type P tumors, this neoplasm does not display ductal differentiation nor areas of squamous differentiation.

Description

Adenocarcinoma, glandular, acinar, cystic, solid with secondary lumens, mammary gland

Age at Necropsy

unknown

Notes

This tumor forms fronds that are reminiscent of fronds observed in type P tumors. However, this neoplasm differs from type P tumors in that the mitotic activity is not most important at the tip of the fronds and ductal differentiation with squamous metaplasia are absent.

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29296
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, acinar, cystic, solid with secondary lumens, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
STOCK Tg(MMTV-S100a4)507Oku
Strain Types
transgenic
General Note
This STOCK genetic background was a mixture of C57BL/6, GRS/A, and CBA.
Strain Synonyms
GRS/A-Tg(MMTVS100a4)xElu
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown