Pathology Image Detail

Caption

Mammary gland: neoplastic lobules are composed of closely-packed glands lined by a one cell-thick cuboidal epithelium. There are also a few solid areas with secondary lumens. Glands and secondary lumens show various degrees of ectasia, and some contain a small to moderate of amorphous acidophilic fluid and occasionally a few desquamated neoplastic cells. Neoplastic cells are cuboidal to polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains small lipid vacuoles and hyaline droplets. The nucleus is central, medium-size to large, round to oval, slightly hypochromatic, with a finely stippled chromatin and 1-3 large basophilic nucleoli. Anisokaryosis and anisocytosis are moderate. A few mitoses are detected. Neoplastic cells occasionally pile-up disorderly.

Description

Adenocarcinoma, glandular, secretory, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29311
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, secretory, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
STOCK Tg(MMTV-Myc)#Led Tg(Wap-BCL2)#Jag
Strain Types
transgenic
General Note
The genetic background of thes mice was a mixture of multiple strains including CD-1, C57BL/6, and DBA/2.
Strain Synonyms
Stock-Tg(WapBcl2)#Wha(MMTVMyc)#Wha
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown