Pathology Image Detail

Caption

Mammary gland: the neoplasm is composed of a few trabeculae and tubules interspersed among ill-defined bundles of neoplastic spindloid cells. There is gradual transition between some of the trabeculae and the spindloid cells. Neoplastic cells with an epithelial phenotype are polygonal, with distinct cell borders and a moderate amount of strongly amphophilic cytoplasm. Neoplastic cells with a mesenchymal phenotype are spindloid to oat-shaped, with distinct cell borders and a moderate amount of delicately fibrillar acidophilic cytoplasm and a slightly elongated hyperchromatic nucleus. The stroma is loose and edematous in the right portion of the photomicrograph, and dense and amorphous in the left portions of the photomicrograph.

Description

Spindle cell carcinoma arising in a glandular carcinoma, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29316
Tumor Name
Mammary gland • carcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Spindle cell carcinoma arising in a glandular carcinoma, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB/N-Tg(WapNotch4)10Rnc/J
Strain Types
transgenic
General Note
The transgene integrated into the X chromosome.
Strain Synonyms
FVB/N-TgN(WapNotch4)10Rnc
FVB/N-Tg(WapInt3)10Rnc
FVB/N-TgN(WapInt3)10Rnc
Int3
FVB-Notch4
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown