Pathology Image Detail

Caption

Mammary gland: neoplastic lobules are composed of closely-packed glands and acini supported by a small to moderate amount of loose fibrovascular stroma. The papillary pattern can be nicely appreciated at this magnification. Neoplastic papillae are massive and are lined by a two cells-thick cuboidal epithelium. The basal layer of cell is indicative of myoepithelial differentiation and is most easily identified in the papillary areas of the neoplasm (half lower right part of the photomicrographs), although it is also present in the glandular portions of the neoplasm (half upper left part of the photomicrograph). Anisokaryosis and anisocytosis are mild.

Description

Adenocarcinoma, papillary, glandular, complex, mammary gland

Age at Necropsy

unknown

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29318
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, papillary, glandular, complex, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
[not specified]-Tg(Wnt1)1Hev
Strain Types
transgenic
General Note
The genetic background of these mice was not fully specified. It contains C57BL/6, SJL, and likely some 129P2/OlaHsd.
Strain Synonyms
STOCK Tg(Wnt1)1Hev
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
unknown