Caption |
Mammary gland: the mammary gland is effaced by a nodular, unencapsulated, densely cellular, well-delineated neoplasm. The neoplasm is composed of solid areas with central necrosis (comedo pattern) at the center of the neoplasm, with the gradual transition to small glandular structures are the periphery of the neoplasm. The solid areas often contain small slit-like lumens with angular contours that can be identified at this low magnification. |
Description |
Adenocarcinoma, solid, glandular, mammary gland |
Age at Necropsy |
unknown |
Notes |
This neoplasm illustrates the most common phenotype of neoplasms arising in mice transgenic for Notch4. Smaller neoplasms tend to be predominantly composed of glandular areas while larger neoplasms generally are predominantly composed of solid areas. However, glandular and solid areas are present in most mammary tumors arising in mice transgenic for Notch4. |
Contributor |
Ward JM (J:107304) |
Pathologist |
Mikaelian I (J:94320) |
Method |
H&E |
