Caption |
Mammary gland: this photomicrograph focuses on the center of the neoplasm where neoplastic cells form thick interconnected trabeculae that often show central liquefactive necrosis (comedo pattern). Although the pattern of the neoplasm is solid, there are numerous slit-like secondary lumens. There is a small to moderate amount of hyalinized fibrovascular stroma. |
Description |
Adenocarcinoma, solid, glandular, mammary gland |
Age at Necropsy |
unknown |
Notes |
This neoplasm illustrates the most common phenotype of neoplasms arising in mice transgenic for Notch4. Smaller neoplasms tend to be predominantly composed of glandular areas while larger neoplasms generally are predominantly composed of solid areas. However, glandular and solid areas are present in most mammary tumors arising in mice transgenic for Notch4. |
Contributor |
Ward JM (J:107304) |
Pathologist |
Mikaelian I (J:94320) |
Method |
H&E |
