Pathology Image Detail

Caption

 Mammary adenocarcinoma: neoplastic cells do not label for alpha-smooth muscle actin. A small number of cells in the fibrovascular stroma of the neoplasm do label for alpha-smooth muscle actin. These cells are interpreted as myofibroblasts and smooth muscle fibers of the vasculature.

Description

 Adenocarcinoma, glandular, solid, mammary gland

Age at Necropsy

 172 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for alpha smooth muscle actin
Image Probes

Type: antibody
Name
anti-alpha smooth muscle actin (A2547)
Target
alpha-smooth muscle actin, N-terminus
Supplier
Sigma-Aldrich
Notes
Monoclonal anti-Alpha Smooth Muscle Actin antibody produced in mouse (raised against N-terminal synthetic decapeptide of alpha-smooth muscle actin). The antibody (also known as anti-a-Sm-1) is specific for the single isoform of alpha-smooth muscle actin.

Model
MMHC ID
MTB:29378
Tumor Name
Mammary gland • adenocarcinoma - solid
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, glandular, solid, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB/N-Tg(WapNotch4)10Rnc/J
Strain Types
transgenic
General Note
The transgene integrated into the X chromosome.
Strain Synonyms
FVB/N-TgN(WapNotch4)10Rnc
FVB/N-Tg(WapInt3)10Rnc
FVB/N-TgN(WapInt3)10Rnc
Int3
FVB-Notch4
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
172 days