Pathology Image Detail

Caption

Trabecular/solid mammary carcinoma: the neoplasm is composed of thick anastomosed trabeculae and solid areas with prominent central necrosis and supported by a small amount of dense fibrovascular stroma. Neoplastic cells are polygonal to oat-shaped, medium-size, eith ill-defined cell borders and with a small to moderate amount of amphophilic cytoplasm. The nucleus is central, round, and slightly hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous. A moderate number of individual cells and small clusters of cells with a pale cytoplasm and a slightly hypochromatic nucleus (arrowheads) are scattered among the other neoplastic cells.

Description

Adenocarcinoma, trabecular, solid, mammary gland

Age at Necropsy

279 days

Contributor

Churchill GA (J:112750)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29387
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, trabecular, solid, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB/N-Tg(WapNotch4)10Rnc/J
Strain Types
transgenic
General Note
The transgene integrated into the X chromosome.
Strain Synonyms
FVB/N-TgN(WapNotch4)10Rnc
FVB/N-Tg(WapInt3)10Rnc
FVB/N-TgN(WapInt3)10Rnc
Int3
FVB-Notch4
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
279 days