Pathology Image Detail

Caption

Trabecular/solid mammary carcinoma: the neoplasm is composed of thick anastomosed trabeculae and solid areas with prominent central necrosis and supported by a small amount of dense fibrovascular stroma. Neoplastic cells are polygonal to oat-shaped, medium-size, eith ill-defined cell borders and with a small to moderate amount of amphophilic cytoplasm. The nucleus is central, round, and slightly hyperchromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.

Description

Adenocarcinoma, trabecular, solid, mammary gland

Age at Necropsy

279 days

Contributor

Churchill GA (J:112750)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29387
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, trabecular, solid, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB/N-Tg(WapNotch4)10Rnc/J
Strain Types
transgenic
General Note
The transgene integrated into the X chromosome.
Strain Synonyms
FVB/N-TgN(WapNotch4)10Rnc
FVB/N-Tg(WapInt3)10Rnc
FVB/N-TgN(WapInt3)10Rnc
Int3
FVB-Notch4
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
279 days