Pathology Image Detail

Caption

 Type P tumor: there is, in almost all areas of ductal differentiation, an almost continuous row of neoplastic cells that label for keratin 5. A very small number of neoplastic cells located in the solid areas also label for keratin 5.

Description

 Type P tumor, mammary gland

Age at Necropsy

 128 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 5
Image Probes

Type: antibody
Name
anti-keratin 5 (PRB-160P) (Covance)
Target
mouse keratin 5, C-terminus
Supplier
Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 5 protein, KFVSTTSSSRRSPKS.

Model
MMHC ID
MTB:29395
Tumor Name
Mammary gland • tumor - type P
Treatment Type
None (spontaneous)
Tumor Synonyms
Type P tumor, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(Wnt1)1Hev/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.
Strain Synonyms
FVB/NJ-Tg(Wnt1)1Hev/J
FVB-Wnt1
FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1
MMTV-Wnt-1 FVB/NJ
MMTV-Wnt-1
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
128 days