Pathology Image Detail

Caption

Mammary gland: neoplastic lobules are separated by a moderate amount of loose fibrovascular stroma. Numerous cystic areas, some containing blood, are scattered throughout the neoplasm. Neoplastic lobules are composed of solid areas with multifocal central cavitation. Nuclear palissading is prominent in the layer of cell in contact with the basement membrane that separate neoplastic cells from the stroma. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a small amount of acidophilic cytoplasm. The nucleus is central, oval, medium-size, and normochromatic. Anisokaryosis and anisocytosis are mild. Mitoses are numerous.

Description

Type P tumor, mammary gland

Age at Necropsy

236 days

Contributor

Churchill GA (J:112750)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29404
Tumor Name
Mammary gland • tumor - type P
Treatment Type
None (spontaneous)
Tumor Synonyms
Type P tumor, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.Cg-Tg(Wnt1)1Hev/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.
Strain Synonyms
FVB/NJ-Tg(Wnt1)1Hev/J
FVB-Wnt1
FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1
MMTV-Wnt-1 FVB/NJ
MMTV-Wnt-1
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
236 days