Caption |
Mammary gland: the neoplasm is composed of thick interconnected trabeculae and solid areas with prominent central necrosis and cavitation. There is a small to moderate amount of dense fibrovascular stroma. Numerous inconspicuous secondary lumens are present throughout the neoplasm. Neoplastic cells aree small to medium-size, polygonal, with indictinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, medium-size, round to oval, hypochromatic, and with 1-3 large basophilic nucleoli. |
Description |
Adenocarcinoma, solid, trabecular, mammary gland |
Age at Necropsy |
364 days |
Notes |
This tumor is not typical of a tumor arising in a mouse transgenic for Wnt1. The genotype of this mouse was checked thrice. Mice transgenic for Wnt1 generally develop type P mammary tumors that are characterized by the formation of structures resembling terminal end buds and ducts, as well as prominent myoepithelial differentiation. All these features are missing from this neoplasm. |
Contributor |
Churchill GA (J:112750) |
Pathologist |
Mikaelian I (J:94320) |
Method |
H&E |
