Caption |
Solid/comedo carcinoma: as exemplified by this photomicrograph, the center of the neoplasm comprised large fibrotic areas. These areas are interpreted as scarred areas that developed secondary to necrosis. Neoplastic cells in these sclerotic areas are arranged in small nests and cords. In addition, a few individual neoplastic cells are scattered throughout this fibrous tissue. |
Description |
Adenocarcinoma, solid, trabecular, mammary gland |
Age at Necropsy |
364 days |
Notes |
This tumor is not typical of a tumor arising in a mouse transgenic for Wnt1. The genotype of this mouse was checked thrice. Mice transgenic for Wnt1 generally develop type P mammary tumors that are characterized by the formation of structures resembling terminal end buds and ducts, as well as prominent myoepithelial differentiation. All these features are missing from this neoplasm. |
Contributor |
Churchill GA (J:112750) |
Pathologist |
Mikaelian I (J:94320) |
Method |
H&E |