Pathology Image Detail

Caption	Mammary gland: the mammary gland is replaced by a large, unencapsulated, well-delineated, locally invasive neoplasm with large areas of lytic necrosis at the center (acidophilic areas with a geographic pattern at the center of the neoplasm). The neoplasm is composed of cords, trabeculae and solid areas separated by a small amount of fibrobvascular stroma. Central necrosis and cavitation are prominent.
Description	Adenocarcinoma, solid, comedo, mammary gland
Age at Necropsy	90 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	H&E

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.