Pathology Image Detail

Caption	Early stage of epithelial to mesenchymal transition: the early stages of epithelial to mesenchymal transition is characterized by the acquisition of a more acidophilic cytoplasm by neoplastic cells while the ability to form lumens is lost. Nucleoli of spindloid neoplastic cells are smaller than nucleoli of epithelial neoplastic cells. Individual neoplastic cells with a spindloid phenotype are present in the stroma (arrowheads). As exemplified in this case, epithelial to mesenchymal transition often occurs at the periphery of the neoplasms.
Description	Adenocarcinoma, glandular, solid, with early epithelial to mesenchymal transition, mammary gland
Age at Necropsy	179 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	H&E

Tumor Synonyms: Adenocarcinoma, glandular, solid, with early epithelial to mesenchymal transition, mammary gland

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.