Pathology Image Detail

Caption	Pancreas: there is severe diffuse interstitial fibrosis with marked atrophy of the exocrine pancreas. The exocrine pancreas that has survived fibrosis has undergone ductal metaplasia and shows small multifocal areas of hyperplasia. Hyperplastic portions of the exocrine pancreas do not show evidence of zymogene production. There is moderate diffuse hyperplasia of islet cells (*).
Description	Pancreas, interstitial fibrosis, severe, diffuse
Age at Necropsy	284 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	H&E

Tumor Synonyms: Pancreas, interstitial fibrosis, severe, diffuse; moderate diffuse hyperplasia of islet cells; exocrine pancreas, ductal metaplasia and small multifocal areas of hyperplasia; pancreatic fibrosis

General Note: Hemizygous mice. The transgene was generated in a (C57BL/6 x DBA/2)F2 genetic background and was subsequently backcrossed to FVB/NJ.