Pathology Image Detail

Caption

 Thyroid gland: the area of adenomatous hyperplasia is composed of variably-sized follicles lined by a cuboidal to low columnar epithelium. The cells are polygonal, large, with a pale delicately vacuolated cytoplasm and a medium-sized, central, hyperchromatic nucleus. Anisokaryosis is mild. Mitoses are not detected.

Description

 Adenomatous hyperplasia, thyroid gland

Age at Necropsy

 284 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 H&E

Model
MMHC ID
MTB:29428
Tumor Name
Thyroid gland - Follicular cell • hyperplasia - adenomatous
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenomatous hyperplasia, thyroid gland
Organ Affected
Thyroid gland - Follicular cell
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(MMTVTGFA)254Rjc/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The transgene was generated in a (C57BL/6 x DBA/2)F2 genetic background and was subsequently backcrossed to FVB/NJ.
Strain Synonyms
FVB/NJ-Tg(MMTVTGFA)254Rjc/J
FVB-Tgfa
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
284 days