Pathology Image Detail

Caption	Solid mammary carcinoma with epithelial to mesenchymal transition: this photomicrograph illustrates a portion of the neoplasm where there is gradual transition between a solid pattern (left side of the photomicrograph) to a spindloid pattern (right side of the photomicrograph) characterized by the formation of interlacing fascicles. The stroma in the solid areas is more abundant and more fibrous than at the periphery of the neoplasm. The stroma is more edematous and less fibrous in the portions of the neoplasm composed of spindloid cells. Neoplastic cells still form a few glands with prominent lumens (arrowheads).
Description	Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland
Age at Necropsy	168 days
Contributor	Ward JM (J:107304)
Pathologist	Mikaelian I (J:94320)
Method	H&E

Tumor Synonyms: Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland

General Note: Hemizygous mice. The founder of this line carried 6 copies of the transgene. "Line C" was the line maintained by the original investigators for further experiments.

Strain Synonyms: FVB/N-TgN(C3(1)/TAg)3Jeg; FVB/N-TgN(C3-1-TAg)3Jeg; FVB/N-TgN(C3-1-TAg)cJeg; C3(1)/SV40 large T antigen; C3(1)/TAg; C3(1)-TAg; FVB/N C3(1)-TAg; line C; PRP-3; C3(1)/T_AG; C3(1)/SV40 TAg; FVB/N C3(1)/TAg; C3(1)SV40 large T antigen; FVB/N C3(1)/T_AG; C3(1)/Tag; C3(1)SV40Tag; C3(1)/SV40 Tag; C3(1)/SV40 large T-antigen; C3(1)/SV40 T/t-antigen; C3(1)/TAg^+/-; T_AG FVB-N; FVB/N C3(1)SV40Tag; C3(1)/SV40 T/t-antigen; C3(1)/simian virus 40 (SV40) T/t-antigens