Pathology Image Detail

Caption

Solid and comedo mammary carcinoma: neoplastic cells are closely packed, medium-size, polygonal, with indistinct cell borders and a small to moderate amount of amphophilic cytoplasm. The nucleus is central, oval, medium-size, with a slightly contoured nuclear membrane, normochromatic, a clumped chromatin and 1-3 small nucleoli. Anisokaryosis and anisocytosis are mild. Mitotic rate is elevated. Neoplastic cells in some places seem to be located in the stroma of the neoplasm and are not separated from the stroma by a discrete basement membrane.

Description

Adenocarcinoma, solid, comedo, mammary gland

Age at Necropsy

140 days

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29436
Tumor Name
Mammary gland • adenocarcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, comedo, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB/N-Tg(C3-1-TAg)cJeg
Strain Types
transgenic
General Note
Hemizygous mice. The founder of this line carried 6 copies of the transgene. "Line C" was the line maintained by the original investigators for further experiments.
Strain Synonyms
FVB/N-TgN(C3(1)/TAg)3Jeg
FVB/N-TgN(C3-1-TAg)3Jeg
FVB/N-TgN(C3-1-TAg)cJeg
C3(1)/SV40 large T antigen
C3(1)/TAg
C3(1)-TAg
FVB/N C3(1)-TAg
line C
PRP-3
C3(1)/TAG
C3(1)/SV40 TAg
FVB/N C3(1)/TAg
C3(1)SV40 large T antigen
FVB/N C3(1)/TAG
C3(1)/Tag
C3(1)SV40Tag
C3(1)/SV40 Tag
C3(1)/SV40 large T-antigen
C3(1)/SV40 T/t-antigen
C3(1)/TAg+/-
TAG FVB-N
FVB/N C3(1)SV40Tag
C3(1)/SV40 T/t-antigen
C3(1)/simian virus 40 (SV40) T/t-antigens
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
140 days