Caption |
Mammary gland: the architecture of a mammary lobule is maintained but the ducts of the mammary glands are obliterated by closely-packed neoplastic cells. Neoplastic cells are composed of several populations of cells. Some of these cells are pale, large, polygonal, with a large hypochromatic and round nucleus. Some other cells are columnar with a slightly elongated hyperchromatic nucleus. Many cells have a phenotype that is intermediate between the two types described above. Cells with a myoepithelial phenotype seem to be partly lining these ducts. The adjacent ducts and alveoli are lined by a cuboidal epithelium that has a "crowded" appearance, although there is no evidence of atypia. Mild to moderate interstitial fibrosis and pleocellular inflammation are presnt at the periphery of the ducts packed with neoplastic cells. |
