Pathology Image Detail

Caption

Mammary gland: the architecture of mammary lobules is preserved. Ducts and acini are mildly distended by a proteinaceous fluid, lipid vacuoles, and desquamated dysplastic cells. They are lined by a cuboidal epithelium where cells generally do not pile-up disordely. Some cells (arrowheads) lining these ducts resemble the "large clear cells", a type of cell that is less differentiated than most of the other luminal cells. There is mild fibrosis and interstitial pleocellular inflammation. The mammary fat pad contains brown fat pad (left portions of the photomicrograph).

Description

Hyperplasia, atypical, mammary gland

Age at Necropsy

140 days

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29438
Tumor Name
Mammary gland • hyperplasia - atypical
Treatment Type
None (spontaneous)
Tumor Synonyms
Hyperplasia, atypical, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB/N-Tg(C3-1-TAg)cJeg
Strain Types
transgenic
General Note
Hemizygous mice. The founder of this line carried 6 copies of the transgene. "Line C" was the line maintained by the original investigators for further experiments.
Strain Synonyms
FVB/N-TgN(C3(1)/TAg)3Jeg
FVB/N-TgN(C3-1-TAg)3Jeg
FVB/N-TgN(C3-1-TAg)cJeg
C3(1)/SV40 large T antigen
C3(1)/TAg
C3(1)-TAg
FVB/N C3(1)-TAg
line C
PRP-3
C3(1)/TAG
C3(1)/SV40 TAg
FVB/N C3(1)/TAg
C3(1)SV40 large T antigen
FVB/N C3(1)/TAG
C3(1)/Tag
C3(1)SV40Tag
C3(1)/SV40 Tag
C3(1)/SV40 large T-antigen
C3(1)/SV40 T/t-antigen
C3(1)/TAg+/-
TAG FVB-N
FVB/N C3(1)SV40Tag
C3(1)/SV40 T/t-antigen
C3(1)/simian virus 40 (SV40) T/t-antigens
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
140 days