Pathology Image Detail

Caption

Mammary gland: the architecture of the mammary gland is preserved. The lumen of the ducts and alveoli of a few acini is moderately distended by closely-packed neoplastic cells. These cells are medium-size, polygonal, with indistinct cell borders and a small amount of amphophilic cytoplasm. The nucleus is central, oval, medium-size, oval, normochromatic, with a finely stippled chromatin and 1-2 inconspicuous basophilic nucleoli. Anisokaryosis and anisocytosis are mild. A few mitoses are present. A few neoplastic cells undergo single cell necrosis. There is mild fibrosis and pleocllular inflammation at the periphery of the affected ducts and acini.

Description

Ductal carcinoma in situ, mammary gland

Age at Necropsy

140 days

Contributor

Ward JM (J:107304)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29439
Tumor Name
Mammary gland • carcinoma in situ - ductal
Treatment Type
None (spontaneous)
Tumor Synonyms
Ductal carcinoma in situ, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB/N-Tg(C3-1-TAg)cJeg
Strain Types
transgenic
General Note
Hemizygous mice. The founder of this line carried 6 copies of the transgene. "Line C" was the line maintained by the original investigators for further experiments.
Strain Synonyms
FVB/N-TgN(C3(1)/TAg)3Jeg
FVB/N-TgN(C3-1-TAg)3Jeg
FVB/N-TgN(C3-1-TAg)cJeg
C3(1)/SV40 large T antigen
C3(1)/TAg
C3(1)-TAg
FVB/N C3(1)-TAg
line C
PRP-3
C3(1)/TAG
C3(1)/SV40 TAg
FVB/N C3(1)/TAg
C3(1)SV40 large T antigen
FVB/N C3(1)/TAG
C3(1)/Tag
C3(1)SV40Tag
C3(1)/SV40 Tag
C3(1)/SV40 large T-antigen
C3(1)/SV40 T/t-antigen
C3(1)/TAg+/-
TAG FVB-N
FVB/N C3(1)SV40Tag
C3(1)/SV40 T/t-antigen
C3(1)/simian virus 40 (SV40) T/t-antigens
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
140 days