Pathology Image Detail

Caption

Haired skin: the neoplasm is composed of tortuous, interconnected, blood-filled vascular spaces separated by a small amount of fibrovascular stroma. Cells lining vascular spaces are large, with indistinct cell borders and with a moderate to large amount of pale acidophilic cytoplasm. The nucleus is large, central, oval, with a contoured nuclear membrane, occasionally folded, hypochromatic, with a delicately stippled chromatin and 2-4 small basophilic nucleoli. Anisokaryosis and anisocytosis are prominent. Mitotic figures are numerous and are often asymmetrical.

Description

Hemangiosarcomas, multiple, subcutis

Age at Necropsy

71 days

Notes

This series of photomicrographs illustrates the different histologic phenotypes of subcutaneous hemangiosarcomas in these mice.

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29444
Tumor Name
Blood vessel • hemangiosarcoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Hemangiosarcomas, multiple, subcutis
Organ Affected
Subcutis
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.129S2(B6)-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Congenic mice homozygous for a targeted mutation of Trp53 (p53).
Strain Synonyms
FVB/NJ-Trp53tm1Tyj
FVB.129S2(B6)-Trp53tm1Tyj
FVB/NJ-Trp53tm1Tyj
FVB.129S2(B6)-Trp53tm1Tyj/J
FVB.129S2-Trp53tm1Tyj/J
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
71 days