Caption |
Haired skin: the subcutis is focally expanded by a nodular, well-delineated, unencapsulated, moderately cellular neoplastic mass. The mass is composed of tortuous, interconnected, blood-filled vascular spaces separated by a small amount of fibrovascular stroma. Cells lining vascular spaces are large, with indistinct cell borders and with a moderate to large amount of pale acidophilic cytoplasm. The nucleus is large, central, oval, with a contoured nuclear membrane, occasionally folded, hypochromatic, with a delicately stippled chromatin and 2-4 small basophilic nucleoli. Anisokaryosis and anisocytosis are moderate. Mitotic figures are numerous are not detected on this photomicrograph. Atypia is less than that observed in other hemangiosarcomas in the same mouse. Hemosiderin-laden macrophages and apoptotic neoplastic cells are scattered throughout the neoplasm. |