Pathology Image Detail

Caption

Haired skin: the subcutis is focally expanded by a nodular, well-delineated, unencapsulated, invasive, moderately to densely cellular cellular neoplastic mass. The mass is composed of ill-defined tortuous, interconnected, blood-filled vascular spaces filled separated by a small amount of fibrovascular stroma and by solid areas composed of neoplastic cells. Cells lining vascular spaces are histiocytoid, large, with indistinct cell borders and with a large amount of acidophilic cytoplasm.

Description

Hemangiosarcomas, multiple, subcutis

Age at Necropsy

71 days

Notes

This series of photomicrographs illustrates the different histologic phenotypes of subcutaneous hemangiosarcomas in these mice.

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29444
Tumor Name
Blood vessel • hemangiosarcoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Hemangiosarcomas, multiple, subcutis
Organ Affected
Subcutis
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.129S2(B6)-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Congenic mice homozygous for a targeted mutation of Trp53 (p53).
Strain Synonyms
FVB/NJ-Trp53tm1Tyj
FVB.129S2(B6)-Trp53tm1Tyj
FVB/NJ-Trp53tm1Tyj
FVB.129S2(B6)-Trp53tm1Tyj/J
FVB.129S2-Trp53tm1Tyj/J
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
71 days