Pathology Image Detail

Caption

Mammary gland: the mammary gland is expanded by a large cystic mass filled with a strongly acidophilic amorphous material. The cysts is lined by a thin layer of epithelial cells that, multifocally, form small papillary projections lined by a one cell-thick cuboidal epithelium. Most neoplastic cells are cuboidal, with indistinct cell borders and a moderate amount of acidophilic cytoplasm. The nucleus is central, medium-sized, oval, and normochromatic. Anisokaryosis and anisocytosis are mild. Mitoses are not detected.

Description

Adenoma, papillary and cystic, mammary gland

Age at Necropsy

225 days

Notes

Mammary tumors arising in these transgenic mice typically are solid carcinomas. Hence, this papillary and cystic adenoma may represent a spontaneous neoplasm rather than a transgene-driven neoplasm.

Contributor

Sundberg J (J:94307)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29445
Tumor Name
Mammary gland • adenocarcinoma - papillary/cystic
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenoma, papillary and cystic, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB/N-Tg(MMTVneu)202Mul/J
Strain Types
transgenic
General Note
Homozygous mice
Strain Synonyms
FVB/N-TgN(MMTVneu)202Mul
MMTV neu
FVBN202
FVBN202 neu
MMTV-erbB2
FVB-Neu
MMTV-Neu
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
225 days