Pathology Image Detail

Caption

Pancreas: a small, nodular, expansile, unencapsulated, well-delineated, densely cellular neoplastic mass is present in the pancreas. This neoplasm is composed of nests and trabeculae separated by a small to moderate amount of loose fibrovascular stroma with large cystic blood-filled vascular spaces. Neoplastic cells are monomorphous, closely-packed, small, with indistinct cell borders and with a small amount of pale basophilic cytoplasm. The nucleus is central, round, normochromatic, with a stippled to clumped chromatin, and occasionalyy a medium-sized basophilic to magenta nucleolus. Mitotic figures are numerous. Anisocytosis and anisokaryosis are minimal.

Description

Islet cell carcinoma, endocrine pancreas

Age at Necropsy

134 days

Notes

The neoplasm is considered malignant in spite of the fact that it is well-delineated and invasive because of the high mitotic rate. Similar variably-sized tumors are present in the pancreas of this mouse.

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29446
Tumor Name
Pancreas - Islet of Langerhans • carcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Islet cell carcinoma, endocrine pancreas
Organ Affected
Pancreas - Islet of Langerhans
Frequency
observed
Reference
J:94320

Strain

Strain
NOD/ShiLt-Tg(Ins2-TAg)1Lt/J
Strain Types
transgenic
General Note
These mice were generated and remain on a NOD/ShiLt genetic background.
Strain Synonyms
NOD-Tg RIP T.2g
NOD/Lt-Tg(Ins2-TAg)1Lt
NOD/Lt-TgN(RipTAg)1Lt
NOD/Lt-Tg(RipTAg)1Lt/J
NOD/ShiLt-Tg(RipTAg)1Lt/J
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
134 days