Pathology Image Detail

Caption

Subcutaneous neoplastic mass: neoplastic cells form small, cavernous, blood-filled, vascular spaces in this portion of the neoplasm. Neoplastic cells in this portion of the neoplasm are medium-sized, histiocytoid to endothelial-like, with indistinct cell borders and with a small amount of strongly acidophilic cytoplasm. The nucleus is central, round to oval, slightly hyperchromatic, with a clumped chromatin and an inconspicuous nucleolus. Anisokaryosis and anisocytosis are mild to moderate.

Description

Hemangiosarcoma, subcutis

Age at Necropsy

50 days

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29451
Tumor Name
Blood vessel • hemangiosarcoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Hemangiosarcoma, subcutis
Organ Affected
Subcutis
Frequency
observed
Reference
J:94320

Strain

Strain
B6.129S2-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background of these mice is congenic C57BL/6J.
Strain Synonyms
B6.129S2-Trp53tm1Tyj
C57BL/6J-Trp53tm1Tyj
p53+/-
p53 heterozygous (+/-)
C57BL/6J-Trp53tm1Tyj
p53(+/-)
B6.129S2-Trp53tm1Tyj
p53+/-
p53+/-
Strain Sex
Male
Reproductive Status
reproductive status not specified
Age of Detection
50 days