Pathology Image Detail

Caption

Mammary gland (mammary lobular hyperplasia): myoepithelial differentiation is evidenced by expression of keratin 14 by a few cells throughout this hyperplastic nodule. These cells are flattened and form a discontinuous layer in the hyperplastic alveoli.

Description

Lobular hyperplasia, mammary gland

Age at Necropsy

212 days

Contributor

Mikaelian I (J:94320)

Pathologist

Mikaelian I (J:94320)

Method

IHC for keratin 14
Image Probes

Type: antibody

Name
anti-keratin 14 (PRB-155P)
Target
mouse keratin 14, C-terminus
Supplier
Biolegend, formerly Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Model

MMHC ID
MTB:29480
Tumor Name
Mammary gland • hyperplasia - lobular
Treatment Type
None (spontaneous)
Tumor Synonyms
Lobular hyperplasia, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
B6D2-Tg(MMTVTGFA)29Rjc/J
Strain Types
transgenic
General Note
The genetic background of these mice is approximately 50% C57BL/6 and approximately 50% DBA/2. Female mice of this strain are unable to suckle their young.
Strain Synonyms
B6D2-Tg(MMTVTGFA)29Rjc
B6D2-TgN(MMTVTGFA)29Rjc
MMTV-TGFα
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
212 days