Pathology Image Detail

Caption	Type P tumor: immunolabelling for keratin 6 is restricted to the suprabasal cells in the areas of ductal differentiation (towards the center of the neoplasm). The fronds of neoplastic cells which mimic terminal end buds of the developing mammary gland do not label for keratin 6.
Description	Type P tumor, mammary gland
Age at Necropsy	73 days
Notes	Myoepithelial differentiation is a prominent feature of type P tumors.
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for keratin 6

Image Probes
Type: antibody	Name anti-keratin 6 (PRB-169P) Target mouse keratin 6, C-terminus Supplier Covance Notes Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 6 protein, KYTTTSSSKKSYRQ.

Model

MMHC ID: MTB:29483

Tumor Name: Mammary gland • adenocarcinoma - type P

Treatment Type: None (spontaneous)

Tumor Synonyms: Type P tumor, mammary gland; Carcinoma, tubular, solid (type P tumor), mammary gland

Organ Affected: Mammary gland

Frequency: observed

Reference: J:94320

Strain

Strain: FVB.Cg-Tg(Wnt1)1Hev/J

Strain Types: congenic; transgenic

General Note: Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.

Strain Synonyms: FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1; FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1; MMTV-Wnt-1 FVB/NJ; MMTV-Wnt-1

Strain Sex: Female

Reproductive Status: reproductive status not specified

Age of Detection: 73 days