Pathology Image Detail

Caption

 Mammary gland: luminal cells label strongly for keratin 14 in a mammary acinus with intra-epithelial neoplasia. Labeling for keratin 14 is weak or absent in myoepithelial cells of the adjacent acini.

Description

 Mammary intra-epithelial neoplasia (MIN), mammary gland

Age at Necropsy

 73 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 14
Image Probes

Type: antibody
Name
anti-keratin 14 (PRB-155P)
Target
mouse keratin 14, C-terminus
Supplier
Biolegend, formerly Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Model
MMHC ID
MTB:29484
Tumor Name
Mammary gland • mammary intraepithelial neoplasia (MIN)
Treatment Type
None (spontaneous)
Tumor Synonyms
Mammary intra-epithelial neoplasia (MIN), mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(Wnt1)1Hev/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.
Strain Synonyms
FVB/NJ-Tg(Wnt1)1Hev/J
FVB-Wnt1
FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1
MMTV-Wnt-1 FVB/NJ
MMTV-Wnt-1
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
73 days