Pathology Image Detail

Caption

 Mammary gland: labeling for keratin 14 is detected in basal and suprabasal cells in the areas of ductal differentiation. Labeling for keratin 14 is not detected in the solid portions of the neoplasm.

Description

 Carcinoma, tubular, solid (type P tumor), mammary gland

Age at Necropsy

 422 days

Notes

 This type of neoplasm is named "type P tumor" in accordance to the current literature. Myoepithelial differentiation is a prominent feature of "type P tumors". Immunolabeling for keratin 17 of "type P tumors" is consistent with the pattern of differentiation named by some authors "follicular/epidermal transdifferentiation".

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 14
Image Probes

Type: antibody
Name
anti-keratin 14 (PRB-155P)
Target
mouse keratin 14, C-terminus
Supplier
Biolegend, formerly Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Model
MMHC ID
MTB:29486
Tumor Name
Mammary gland • adenocarcinoma - type P
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma, tubular, solid (type P tumor), mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(Wnt1)1Hev/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.
Strain Synonyms
FVB/NJ-Tg(Wnt1)1Hev/J
FVB-Wnt1
FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1
MMTV-Wnt-1 FVB/NJ
MMTV-Wnt-1
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
422 days