Pathology Image Detail

Caption

 Type P tumor: a discontinuous row of alpha-smooth mucsle actin-positive cells surrounds fronds of neoplastic cells. In addition, scattered luminal cells that occasionally form small duct-like structures also label for alpha-smooth muscle actin. Myeopithelial cells that strongly label for alpha-smooth muscle actin form a continuous row of cells in a non-neoplastic mammary duct (right portion of the figure).

Description

 Type P tumor, mammary gland

Age at Necropsy

 149 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for alpha smooth muscle actin
Image Probes

Type: antibody
Name
anti-alpha smooth muscle actin (A2547)
Target
alpha-smooth muscle actin, N-terminus
Supplier
Sigma-Aldrich
Notes
Monoclonal anti-Alpha Smooth Muscle Actin antibody produced in mouse (raised against N-terminal synthetic decapeptide of alpha-smooth muscle actin). The antibody (also known as anti-a-Sm-1) is specific for the single isoform of alpha-smooth muscle actin.

Model
MMHC ID
MTB:29488
Tumor Name
Mammary gland • adenocarcinoma - type P
Treatment Type
None (spontaneous)
Tumor Synonyms
Type P tumor, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(Wnt1)1Hev/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.
Strain Synonyms
FVB/NJ-Tg(Wnt1)1Hev/J
FVB-Wnt1
FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1
MMTV-Wnt-1 FVB/NJ
MMTV-Wnt-1
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
149 days