Pathology Image Detail

Caption	Mammary adenocarcinoma, glandular with epithelial to mesenchymal transition: strong cytoplasmic labeling for keratin 14 is detected in scattered cells with a basal phenotype located in the glandular portions of the neoplasm as well as in spindloid cells.
Description	Adenocarcinoma, glandular with epithelial to mesenchymal transition, mammary gland
Age at Necropsy	257 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for keratin 14

Image Probes
Type: antibody	Name anti-keratin 14 (PRB-155P) Target mouse keratin 14, C-terminus Supplier Biolegend, formerly Covance Notes Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Model

MMHC ID: MTB:29490

Tumor Name: Mammary gland • adenocarcinoma

Treatment Type: None (spontaneous)

Tumor Synonyms: Adenocarcinoma, glandular with epithelial to mesenchymal transition, mammary gland

Organ Affected: Mammary gland

Frequency: observed

Reference: J:94320

Strain

Strain: FVB.Cg-Tg(Wnt1)1Hev/J

Strain Types: congenic; transgenic

General Note: Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.

Strain Synonyms: FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1; FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1; MMTV-Wnt-1 FVB/NJ; MMTV-Wnt-1

Strain Sex: Female

Reproductive Status: reproductive status not specified

Age of Detection: 257 days