Pathology Image Detail

Caption	Glandular mammary adenocarcinoma with epithelial to mesenchymal transition: there is moderate immunolabeling of neoplastic cells with a spindloid phenotype for vimentin. Neoplastic cells with an epithelial phenotype do not label for vimentin.
Description	Adenocarcinoma, glandular with epithelial to mesenchymal transition, mammary gland
Age at Necropsy	257 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for vimentin

Image Probes
Type: antibody	Name anti-vimentin Target human vimentin (VIM) Supplier Biomeda Corporation Notes polyclonal rabbit anti-human vimentin

Model

MMHC ID: MTB:29490

Tumor Name: Mammary gland • adenocarcinoma

Treatment Type: None (spontaneous)

Tumor Synonyms: Adenocarcinoma, glandular with epithelial to mesenchymal transition, mammary gland

Organ Affected: Mammary gland

Frequency: observed

Reference: J:94320

Strain

Strain: FVB.Cg-Tg(Wnt1)1Hev/J

Strain Types: congenic; transgenic

General Note: Hemizygous mice. The transgene was generated on a C57BL/6 x SJL background. It was subsequently backcrossed onto FVB/NJ.

Strain Synonyms: FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1; FVB/NJ-Tg(Wnt1)1Hev/J; FVB-Wnt1; MMTV-Wnt-1 FVB/NJ; MMTV-Wnt-1

Strain Sex: Female

Reproductive Status: reproductive status not specified

Age of Detection: 257 days