Pathology Image Detail

Caption

 Solid mammary carcinoma with epithelial to mesenchymal transition: spindloid neoplastic cells label moderately for vimentin while epithelial neoplastic cells do not label for vimentin.

Description

 Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland

Age at Necropsy

 251 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for vimentin
Image Probes

Type: antibody
Name
anti-vimentin
Target
human vimentin (VIM)
Supplier
Biomeda Corporation
Notes
polyclonal rabbit anti-human vimentin

Model
MMHC ID
MTB:29491
Tumor Name
Mammary gland • adenocarcinoma - solid
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
251 days