Pathology Image Detail

Caption

 Epithelial to mesenchymal transition: a few spindloid neoplastic cells label moderately for keratin 17. In addition, one neoplastic cell with the morphology of a myoepithelial cell labels strongly for keratin 17 (arrowhead).

Description

 Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland

Age at Necropsy

 251 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 17
Image Probes

Type: antibody
Name
anti-keratin 17
Target
mouse and human keratin 17 (recombinant, C terminal)
Notes
polyclonal rabbit anti-mouse keratin 17 antibody (kind gift of Dr. Pierre Coulombe, Johns Hopkins University School of Medicine)

Model
MMHC ID
MTB:29491
Tumor Name
Mammary gland • adenocarcinoma - solid
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
251 days