Pathology Image Detail

Caption

Mammary carcinoma with epithelial to mesenchymal transition: approximately 30% spindloid neoplastic cells label weakly to moderately for keratin 14.

Description

Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland

Age at Necropsy

251 days

Contributor

Churchill GA (J:112750)

Pathologist

Mikaelian I (J:94320)

Method

IHC for keratin 14
Image Probes

Type: antibody

Name
anti-keratin 14 (PRB-155P)
Target
mouse keratin 14, C-terminus
Supplier
Biolegend, formerly Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Model

MMHC ID
MTB:29491
Tumor Name
Mammary gland • adenocarcinoma - solid
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
251 days