Pathology Image Detail

Caption

 Mammary carcinoma with epithelial to mesenchymal transition: a moderate number of spindloid neoplastic cells label moderately for keratin 5. A fw cells with a myoepithelial phenotype (arrowheads) also label for keratin 5.

Description

 Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland

Age at Necropsy

 251 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 5
Image Probes

Type: antibody
Name
anti-keratin 5 (PRB-160P) (Covance)
Target
mouse keratin 5, C-terminus
Supplier
Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 5 protein, KFVSTTSSSRRSPKS.

Model
MMHC ID
MTB:29491
Tumor Name
Mammary gland • adenocarcinoma - solid
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
251 days