Pathology Image Detail

Caption	Mammary carcinoma with epithelial to mesenchymal transition: there is moderate labeling of neoplastic spindloid cells for alpha smooth muscle actin.
Description	Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland
Age at Necropsy	251 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for alpha smooth muscle actin

Image Probes
Type: antibody	Name anti-alpha smooth muscle actin (A2547) Target alpha-smooth muscle actin, N-terminus Supplier Sigma-Aldrich Notes Monoclonal anti-Alpha Smooth Muscle Actin antibody produced in mouse (raised against N-terminal synthetic decapeptide of alpha-smooth muscle actin). The antibody (also known as anti-a-Sm-1) is specific for the single isoform of alpha-smooth muscle actin.

Tumor Synonyms: Adenocarcinoma, solid, with epithelial to mesenchymal transition, mammary gland

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.