Pathology Image Detail

Caption

 Mammary adenocarcinoma, immunolabeling for keratin 17: scattered neoplastic cells with a basal (myoepithelial) and other neoplastic cells with a luminal phenotype show strong cytplasmic labeling for keratin 17. Spindloid cells label weakly or do not label for keratin 17.

Description

 Adenocarcinoma with epithelial to mesenchymal transition, mammary gland

Age at Necropsy

 229 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 17
Image Probes

Type: antibody
Name
anti-keratin 17
Target
mouse and human keratin 17 (recombinant, C terminal)
Notes
polyclonal rabbit anti-mouse keratin 17 antibody (kind gift of Dr. Pierre Coulombe, Johns Hopkins University School of Medicine)

Model
MMHC ID
MTB:29492
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
229 days