Pathology Image Detail

Caption	Solid mammary carcinoma: a moderate number of neoplastic cells label strongly for keratin 5. Most of these keratin 5-positive cells are suprabasal, although some have a myoepithelial phenotype (arrowheads). A few neoplastic cells scattered in the areas of epithelial to mesenchymal transition (*) also show strong cytoplasmic labeling for keratin 5.
Description	Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland
Age at Necropsy	250 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for keratin 5

Image Probes
Type: antibody	Name anti-keratin 5 (PRB-160P) (Covance) Target mouse keratin 5, C-terminus Supplier Covance Notes Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 5 protein, KFVSTTSSSRRSPKS.

Tumor Synonyms: Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.