Pathology Image Detail

Caption	Solid mammary carcinoma (area of epithelial to mesenchymal transition): a moderate number of basal and suprabasal cells in the solid portions of the neoplasm label strongly for keratin 14. Most spindloid cells of the area of epithelial to mesenchymal transition show strong cytoplasmic labeling for keratin 14.
Description	Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland
Age at Necropsy	250 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for keratin 14

Image Probes
Type: antibody	Name anti-keratin 14 (PRB-155P) Target mouse keratin 14, C-terminus Supplier Biolegend, formerly Covance Notes Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Tumor Synonyms: Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.