Pathology Image Detail

Caption	Solid mammary carcinoma (area of epithelial to mesenchymal transition): most spindloid cells of the area of epithelial to mesenchymal transition show weak cytoplasmic labeling for involucrin. Neoplastic cells with an epithelial phenotype do not label for involucrin.
Description	Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland
Age at Necropsy	250 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for involucrin

Image Probes
Type: antibody	Name anti-involucrin (PRB-142C) Target involucrin (full length) Supplier Covance Notes polyclonal rabbit anti-mouse antibody

Tumor Synonyms: Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.