Pathology Image Detail

Caption

 Solid mammary carcinoma (area of epithelial to mesenchymal transition): neoplastic cells with an epithelial phenotype show mild cytoplasmic labeling for trichohyalin. Spindloid cells do not label for trichohyalin.

Description

 Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland

Age at Necropsy

 250 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for trichohyalin
Image Probes

Type: antibody
Name
anti-trichohyalin
Target
trichohyalin (Thh)
Notes
monoclonal antibody against trichohyalin (kind gif of Dr. T.T. Sun, AE15)

Model
MMHC ID
MTB:29493
Tumor Name
Mammary gland • carcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
250 days