Pathology Image Detail

Caption	Solid mammary carcinoma (area of epithelial to mesenchymal transition): most spindloid cells of the area of epithelial to mesenchymal transition show strong cytoplasmic labeling for keratins 8/18. Neoplastic cells with an epithelial phenotype weakly label for keratins 8/18.
Description	Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland
Age at Necropsy	250 days
Contributor	Churchill GA (J:112750)
Pathologist	Mikaelian I (J:94320)
Method	IHC for keratins 8 and 18

Image Probes
Type: antibody	Name anti-keratins 8 and 18 (CBL170) Target human keratin 8 and 18 Supplier Chemicon Notes Monoclonal antibody raised against cytokeratins from human breast carcinoma cell line MCF-7.

Tumor Synonyms: Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland

General Note: Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.